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Weak/Comprehensive Metabolizers, CYP2D6 The formation of the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Around 7% on the inhabitants has lessened exercise in the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme process. These men and women are “bad metabolizers” of debrisoquine, dextromethorphan and tricyclic